Network physiology reveals relations between network topology and physiological function

作者：Bashan, Amir; Bartsch, Ronny P.; Kantelhardt, Jan. W.; Havlin, Shlomo; Ivanov, Plamen Ch^*

来源：Nature Communications, 2012, 3(1): 702.

DOI：10.1038/ncomms1705

• HEART-RATE
• PHYLOGENETIC ANALYSIS
• SLEEP
• CONNECTIVITY
• EVOLUTION
• FEEDBACK
• FAILURE

The human organism is an integrated network where complex physiological systems, each with its own regulatory mechanisms, continuously interact, and where failure of one system can trigger a breakdown of the entire network. Identifying and quantifying dynamical networks of diverse systems with different types of interactions is a challenge. Here we develop a framework to probe interactions among diverse systems, and we identify a physiological network. We find that each physiological state is characterized by a specific network structure, demonstrating a robust interplay between network topology and function. Across physiological states, the network undergoes topological transitions associated with fast reorganization of physiological interactions on time scales of a few minutes, indicating high network flexibility in response to perturbations. The proposed system-wide integrative approach may facilitate the development of a new field, Network Physiology.

• 出版日期2012-2