Aminothiophenedicarboxamides and dicyanothiopheneacetamides as effective synthetic molluscicides against Indoplanorbis exustus snail

作者：Kanawade Shrikant B; Toche Raghunath B^*; Patil Shivaraj P; Desai Ashok E; Bhamare Sapana S

来源：European Journal of Medicinal Chemistry, 2011, 46(9): 4682-4686.

DOI：10.1016/j.ejmech.2011.06.001

• Thiophenedicarbonitrile
• Thiophenedicarboxamide
• Thiophenedicyanoacetamide
• Molluscicidal activity
• Indoplanorbis exustus snail

New thiophenedicarboxamide 2a-c and dicyanothiopheneacetamide 3a-c derivatives were synthesized and their bioactivity against Indoplanorbis exustus snails was evaluated. The I. exustus snail is a serious host of parasite of genus Schistosoma which infects cattle. Thus reduces livestock productivity and also acts as a source of cercarial dermatitis in human beings. The results obtained show a significant (P < 0.05) molluscicidal activity with LC50 = 0.6043 ppm for compound 2a and LC50 = 0.6511 ppm for compound 3a.

• 出版日期2011-9