Noteworthy observations accompanying synthesis of the apoptolidin disaccharide

作者：Srinivasarao Madduri; Park Taesik; Chen Yuzhong; Fuchs Philip L^*

来源：Chemical Communications, 2011, 47(20): 5858-5860.

DOI：10.1039/c1cc11448d

A stereoselective synthesis of the apoptolidin disaccharide is reported. The key chemistry features a new transformation utilizing a highly selective tetramethylalkoxyalanate[V]-directed syn-methylation of a vinylogous ester, isolation of a hydrate of a 2-keto sugar, an eco-friendly radical cleavage of a bromomethyl group, and an efficient preparation of a fluorodisaccharide via the use of XtalFluor-E.

• 出版日期2011