Antioxidant and anti-aging activities of the polysaccharide TLH-3 from Tricholoma lobayense

作者：Ding, Qiuying; Yang, Dan; Zhang, Wenna; Lu, Yongming; Zhang, Mingzhu; Wang, Liming; Li, Xuehui; Zhou, Liyuan; Wu, Qingxi; Pan, Wenjuan; Chen, Yan^*

来源：International Journal of Biological Macromolecules, 2016, 85: 133-140.

DOI：10.1016/j.ijbiomac.2015.12.058

• Antioxidant activity
• Anti-aging activity
• Tricholoma lobayense polysaccharide TLH-3

Polysaccharides from edible fungi usually exhibit many bioactivities. Our previous studies found that polysaccharide TLH-3 extracted from Tricholoma lobayense possessed noticeable antioxidant activity. To further explore its biological activities, the antioxidant and anti-aging activities of TLH-3 were evaluated in vitro and in vivo. The results of antioxidant activity in vitro showed that TLH-3 could enhance the cell viability, reduce the production of reactive oxygen species (ROS) and inhibit oxidative damage induced by tert-butylhydroperoxide (t-BHP) in human embryonic lung fibroblasts (HELF) cells. The anti-aging capability was measured in D-galactose (D-gal)-induced aged mice model, and the experimental data showed that TLH-3 significantly inhibited the formation of malondialdehyde (MDA) and raised the activities of superoxide dismutase (SOD) and catalase (CAT) in mice liver and serum (p < 0.05). This study suggested that TLH-3 possessed apparent antioxidant and anti-aging activities and could be exploited as a potent dietary supplement to attenuate aging and prevent age-related diseases in humans.

• 出版日期2016-4
• 单位安徽大学