Luminescence of coelenterazine derivatives with C-8 extended electronic conjugation

作者：Yuan, Ming-Liang; Jiang, Tian-Yu; Du, Lu-Pei; Li, Min-Yong^*

来源：Chinese Chemical Letters, 2016, 27(4): 550-554.

DOI：10.1016/j.cclet.2016.02.011

• Bioluminescence imaging
• Coelenterazine derivatives
• Relative quantum yield
• Chemiluminescence
• Red-shifted

Replacement of the methylene group at the C-8 position with an extended electronic conjugation is a new promising method to develop red-shifted coelenterazine derivatives. In this paper, we have described an oxygen-containing coelenterazine derivative with a significant red-shifted (63 nm) bioluminescence signal maximum relative to coelenterazine 400a (DeepBlueC (TM), 1). In cell imaging, the sulfur-containing coelenterazine derivative displayed a significantly (1.77 +/- 0.09; P <= 0.01) higher luminescence signal compared to coelenterazine 400a and the oxygen-containing coelenterazine derivative exhibited a slightly (0.74 +/- 0.08; P <= 0.05) lower luminescence signal. It is beneficial to understand further the underlying mechanisms of bioluminescence.

• 出版日期2016-4
• 单位山东大学