Anterior 90 degrees Partial vs Nissen Fundoplication-5 Year Follow-Up of a Single-Centre Randomised Trial

作者：Watson David Ian^*; Devitt Peter G; Smith Lorelle; Jamieson Glyn G

来源：Journal of Gastrointestinal Surgery, 2012, 16(9): 1653-1658.

DOI：10.1007/s11605-012-1920-8

• Gastro-esophageal reflux disease
• Nissen fundoplication
• Anterior partial fundoplication
• Laparoscopy
• Randomised controlled trial

Nissen fundoplication can be followed by side effects, and this has driven modifications, including partial fundoplications. We previously reported early outcomes from a randomised trial of Nissen vs anterior 90A degrees partial fundoplication. This paper reports 5-year follow-up outcomes to determine whether anterior 90A degrees fundoplication achieves a satisfactory longer-term outcome. %26lt;br%26gt;From February 1999 to August 2003, 79 patients were randomised to Nissen vs anterior 90A degrees fundoplication. Patients were followed yearly using a standardized clinical questionnaire which included symptom scores to assess heartburn, dysphagia, other post-fundoplication side effects and overall satisfaction with the outcome. Five-year clinical outcomes were analysed. %26lt;br%26gt;Seventy-four patients were available for follow-up at 5 years. There were no significant differences for heartburn or satisfaction, although more patients used antisecretory medication after anterior 90A degrees fundoplication (29.7 vs 8.1 %). Dysphagia was greater after Nissen fundoplication when measured by an analogue score for solid food and a composite dysphagia score. Symptoms of bloating were more common following Nissen fundoplication (80.0 vs 32.4 %), and less patients could eat a normal diet (78.4 vs 94.6 %). Re-operation was undertaken in four patients after Nissen fundoplication (dysphagia, three; hiatus hernia, one) vs three after anterior 90A degrees fundoplication (recurrent reflux, three). %26lt;br%26gt;At 5 years, anterior 90A degrees partial fundoplication was associated with less side effects, offset by greater use of antisecretory medication. Reflux symptoms and overall satisfaction were similar to Nissen fundoplication. Laparoscopic anterior 90A degrees partial fundoplication is an effective treatment for gastro-esophageal reflux.

• 出版日期2012-9