Glypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: a preliminary study

作者：Mendes Ramon Barreto; Dias Rosane Borges; Figueiredo Andreia Leal; Gurgel Clarissa Araujo; Santana Filho Manoel; Melo Leonardo Araujo; Trierveiler Marilia; Cury Patricia Ramos; Leonardi Rosalia; Dos Santos Jean Nunes^*

来源：Journal of Oral Pathology & Medicine, 2017, 46(4): 297-300.

DOI：10.1111/jop.12501

• ameloblastoma
• glypican-3
• keratocystic odontogenic tumor
• odontogenic tumors

BACKGROUND: Glypican-3 is a cell surface proteoglycan that is found in embrionary tissues, and there are no studies investigating this protein in odontogenic tumor. Thus, the aim of this study was to investigate glypican-3 in a series of aggressive and non-aggressive odontogenic tumors.
METHODS: Fifty-nine cases of tumors were divided into aggressive odontogenic tumors (20 solid ameloblastomas, four unicystic ameloblastoma, 28 KOTs including five associated with Gorlin-Goltz syndrome) and non-aggressive odontogenic tumors (five adenomatoid odontogenic tumors and two calcifying cystic odontogenic tumors) and analyzed for glypican-3 using immunohistochemistry.
RESULTS: Glypican-3 was observed in seven solid ameloblastoma and eighteen keratocystic odontogenic tumors including three of the five syndromic cases, but there was no significant difference between syndromic and sporadic cases (P > 0.05; Fisher's exact Test). All cases of unicystic ameloblastoma (n = 4), adenomatoid odontogenic tumor (n = 5), and calcifying cystic odontogenic tumor (n = 2) were negative.
CONCLUSIONS: This provided insights into the presence of glypican-3 in odontogenic tumors. This protein distinguished aggressive from non-aggressive odontogenic tumors.

• 出版日期2017-4