A photoluminescent nanocrystal-based signaling protocol highly sensitive to nerve agents and highly toxic organophosphate pesticides

作者:Yu Tao; Shen Jiang Shan; Bai Hai Hong; Guo Lei; Tang Ji Jun; Jiang Yun Bao*; Xie Jian Wei
来源:Analyst, 2009, 134(10): 2153-2157.
DOI:10.1039/b915159c

摘要

A photoluminescent II-VI group semiconductor nanocrystal (NC)-based signaling platform composed of thioglycolic acid capped CdS NCs and acetylcholinesterase-acetylthiocholine enzyme catalytic reaction system was developed that was shown to be highly sensitive to nerve agents and toxic organophosphate pesticides with detection limits down to sub-nM levels. This new sensing protocol does not require troublesome conjugation of biomacromolecules onto the surface of NCs.