Size-dependent antimicrobial response of zinc oxide nanoparticles

作者：Palanikumar Loganathan^*; Ramasamy Sinna Nadar; Balachandran Chandrasekaran

来源：IET Nanobiotechnology, 2014, 8(2): 111-117.

DOI：10.1049/iet-nbt.2012.0008

• ZnO
• antibacterial activity
• biomedical materials
• cellular biophysics
• Fourier transform spectra
• II-VI semiconductors
• infrared spectra
• microorganisms
• nanofabrication
• nanoparticles
• particle size
• pH
• precipitation (physical chemistry)
• semiconductor growth
• transmission electron microscopy
• wide band gap semiconductors
• X-ray diffraction
• zinc compounds
• nanomedicine
• size-dependent antimicrobial activity
• zinc oxide nanoparticles
• antibacterial activities
• antifungal activities

Antibacterial and antifungal activities of zinc oxide nanoparticles (ZnO NPs) were investigated against infectious microorganisms. ZnO NPs were prepared by wet chemical precipitation method varying the pH values. Particle size and morphology of the as-prepared ZnO powders were characterised by X-ray diffraction, Fourier transform infrared spectroscopy and transmission electron microscope. The zone of inhibition by NPs ranged from 0 to 17 mm. The lowest minimum inhibitory concentration value of NPs is 25 mu g.ml(-1) against Staphylococcus epidermidis. These studies demonstrate that ZnO NPs have wide range of antimicrobial activities towards various microorganisms. The results obtained in the authors' study indicate that the inhibitory efficacy of ZnO NPs is significantly dependent on its chosen concentration and size. Significant inhibition in antibacterial response was observed for S. epidermidis when compared with control antibiotic.

• 出版日期2014-6