A New Polyketide from the Mangrove Endophytic Fungus Penicillium sp sk14JW2P

作者：Huang, Xi-Shan; Yang, Bin; Sun, Xue-Feng; Xia, Guo-Ping; Liu, Ya-Yue; Ma, Lin; She, Zhi-Gang^*

来源：Helvetica Chimica Acta, 2014, 97(5): 664-668.

DOI：10.1002/hlca.201300248

• Penicillium
• Fungi
• Polyketides
• Palitantin
• Acetylcholinesterase (AchE) inhibitory activity
• X-Ray crystallography

Two polyketides were isolated from the mangrove endophytic fungus, Penicillium sp. sk14JW2P, and one derivative with a modified structure. The structures were elucidated by spectroscopic analyses, the structure of the compound 1 was further confirmed by single-crystal X-ray diffraction, and its absolute configuration was determined. Compound 1 and 2 showed acetylcholinesterase (AchE) inhibitory activities with IC50 values of 12 +/- 0.3 and 79 +/- 2nM, respectively.

• 出版日期2014-5
• 单位中山大学