α-Tocospiro C, a novel cytotoxic α-tocopheroid from Cirsium setosum

作者：Yuan, Zhenzhen; Duan, Hongmei; Xu, Yingying; Wang, Ali; Gan, Lishe; Li, Jinjie; Liu, Mingtao^*; Shang, Xiaoya

来源：Phytochemistry Letters, 2014, 8: 116-120.

DOI：10.1016/j.phytol.2014.02.007

• Cirsium setosum
• alpha-Tocospiro C
• Absolute configuration
• Cytotoxic activities

alpha-Tocospiro C (1), the first example of nor-alpha-tocopheroid possessing unusual 7,8-dimethyl-1-oxaspiro[ 4.4] non-7-ene-6,9-dione carbon skeleton, was isolated and characterized from Cirsium setosum. Its structure and absolute configuration were determined by extensive spectroscopic methods, especially 2D NMR and ECD data analysis. The biosynthetic pathway was postulated. alpha-Tocospiro C (1) exhibited significant selective cytotoxic activities against human colon cancer (HCT8) cells, with IC50 values of 0.03 mu M.

• 出版日期2014-5
• 单位浙江大学; 北京中医药大学; 北京联合大学