Autoantibodies as diagnostic biomarkers for the detection and subtyping of multiple sclerosis

作者：DeMarshall Cassandra; Goldwaser Eric L; Sarkar Abhirup; Godsey George A; Acharya Nimish K; Thayasivam Umashanger; Belinka Benjamin A; Nagele Robert G^*

来源：Journal of Neuroimmunology, 2017, 309: 51-57.

DOI：10.1016/j.jneuroim.2017.05.010

• Multiple sclerosis
• Autoantibodies
• Diagnostics
• Biomarkers
• Blood biomarkers
• Microarray

The goal of this preliminary proof-of-concept study was to use human protein microarrays to identify blood based autoantibody biomarkers capable of diagnosing multiple sclerosis (MS). Using.sera from 112 subjects, including 51 MS subjects, autoantibody biomarkers effectively differentiated MS subjects from age- and gender matched normal and breast cancer controls with 95.0% and 100% overall accuracy, but not from subjects with Parkinson's disease. Autoantibody biomarkers were also useful in distinguishing subjects with the relapsing remitting form of MS from those with the secondary progressive subtype. These results demonstrate that autoantibodies can be used as noninvasive blood-based biomarkers for the detection and subtyping of MS.

• 出版日期2017-8-15