Necrotizing Sarcoid Granulomatosis with Natural Resolution after a Surgical Lung Biopsy

作者：Shibata Takayuki; Takahashi Koichiro^*; Uchida Masaru; Yamasaki Fumio; Kawashima Michihiro; Sueoka Aragane Naoko

来源：Internal Medicine, 2018, 57(11): 1625-1629.

DOI：10.2169/internalmedicine.9813-17

• necrotizing sarcoid granulomatosis
• multiple nodular shadows
• natural recovery
• surgical lung biopsy

Necrotizing sarcoid granulomatosis (NSG) is a rare disease that is diagnosed based on pathological findings. We herein report the case of a 27-year-old man who had multiple nodular shadows in bilateral lung fields on chest radiography and elevated levels of C-reactive protein (CRP). The pathological evaluation of a lung biopsy specimen showed the infiltration of lymphocytes, granulomas with necrosis and granulomatous angiitis. He was therefore diagnosed with NSG. He has been followed without treatment, as his fever and CRP levels decreased immediately after the surgical lung biopsy. Thereafter, the pulmonary nodular shadows gradually recovered without any treatment within a few months. Our experience suggests the possibility that surgical invasion might trigger an improvement in disease activity.

• 出版日期2018