A DFT Study on the Mechanism of the FLP-access to N-Arylazacycles from Cyclic Ethers: Sequential Activation of Two C-O Bonds

作者：Huo Yan; Xu Yi; Wang Zhihong^*

来源：Chemistry Letters, 2017, 46(11): 1664-1667.

DOI：10.1246/cl.170633

• Frustrated Lewis pair
• C-O bond activation
• DFT study

Computational studies suggested that the B(C6F5)(3)-catalyzed synthesis of N-arylpyrrolidines from arylamines and cyclic ethers was achieved via two consecutive C-O bond activation steps by the generation of a frustrated Lewis pair. The formation of the Lewis acid-base adduct between B(C6F5)(3) and THF was crucial in the ring opening of THF while the existence of FLP was also indispensable in the cyclization process.

• 出版日期2017-9
• 单位南开大学