Deprivation and faecal haemoglobin: implications for bowel cancer screening

作者：Digby Jayne; McDonald Paula J; Strachan Judith A; Libby Gillian; Steele Robert J C; Fraser Callum G^*

来源：Journal of Medical Screening, 2014, 21(2): 95-97.

DOI：10.1177/0969141314535388

• Colorectal cancer
• deprivation
• faecal haemoglobin
• faecal immunochemical test
• screening

Objective: To investigate the relationship between deprivation and faecal haemoglobin concentration (f-Hb). %26lt;br%26gt;Setting: Scottish Bowel Screening Programme. %26lt;br%26gt;Methods: A total of 66725 men and women, aged 50 to 74, were invited to provide a single sample for a faecal immunochemical test. Deprivation was estimated using the Scottish Index of Multiple Deprivation quintiles: f-Hb was measured (OC-Sensor, Eiken, Japan) on 38439 participants. The relationship between deprivation quintiles and f-Hb was examined. %26lt;br%26gt;Results: Median age was 60 years, 53.6% women, with 14.1%, 19.7%, 17.7%, 25.9% and 22.6% in the lowest to the highest deprivation quintiles respectively. No detectable f-Hb was found in 51.9%, ranging from 45.5% in the most deprived up to 56.5% in the least deprived. As deprivation increased, f-Hb increased (p%26lt;0.0001). This trend remained controlling for sex and age (p%26lt;0.001). Participants in the most deprived quintile were more likely to have a f-Hb above a cut-off of 80 mu g Hb/g faeces compared with the least deprived, independent of sex and age (adjusted odds ratio 1.70, 95% confidence interval: 1.37 to 2.11). %26lt;br%26gt;Conclusions: Deprivation and f-Hb are related. This has important implications for selection of cut-off f-Hb for screening programmes, and supports the inclusion of deprivation in risk-scoring systems.

• 出版日期2014