Development of a histone deacetylase 6 inhibitor and its biological effects

作者：Lee Ju Hee; Yao Yuanshan; Mahendran Adaickapillai; Ngo Lang; Venta Perez Gisela; Choy Megan L; Breslow Ronald^*; Marks Paul A

来源：Proceedings of the National Academy of Sciences of the United States of America, 2015, 112(39): 12005-12010.

DOI：10.1073/pnas.1515882112

• HDAC
• tubulin
• cancer

We report the development of a potent, selective histone deacetylase 6 (HDAC6) inhibitor. This HDAC6 inhibitor blocks growth of normal and transformed cells but does not induce death of normal cells. The HDAC6 inhibitor alone is as effective as paclitaxel in anticancer activity in tumor-bearing mice.

• 出版日期2015-9-29