Androgen receptor blockade in the posterodorsal medial amygdala impairs sexual odor preference in male rats

作者：Hosokawa Nami; Chiba Atsuhiko^*

来源：Hormones and Behavior, 2010, 58(3): 493-500.

DOI：10.1016/j.yhbeh.2010.04.010

• Odor preference
• Androgen receptor
• Amygdala
• Male rats
• Flutamide

The present study was designed to investigate the role of androgen in the medial amygdala (MeA) in the expression of sexual odor preference in male rats. Gonadally intact, sexually experienced male rats received bilateral administration of flutamide, an androgen receptor (AR) blocker, aimed at either the posterior dorsal part (MePD) or the anterior dorsal part (MeAD) of the MeA through inner cannulae inserted into the implanted guide cannulae. Prior to flutamide administration, all subjects spent longer sniffing volatile odors from an estrous female than those from a sexually active male. Experiment 1 demonstrated that the preference for the female odors over the male odors was eliminated during flutamide administration into the MePD, but not into either the MeAD or outside MePD/MeAD. This elimination of the female-directed odor preference resulted from increase of time sniffing the male odors rather than decrease of time sniffing the estrous odors. In Experiment 2, odor discrimination tests confirmed that the flutamide administration into the MePD did not induce impairment in the ability of the subjects to discriminate the estrous odors from the male odors. These results demonstrated that activation of AR in the MePD plays a critical role in the expression of the preference for estrous odors over male odors. AR blockade, however, seemed to induce a preference for male odors rather than reduce the existing preference for estrous odors, suggesting a complicated regulation of sexual odor preference by sex steroids.

• 出版日期2010-8