Design, synthesis and antimycobacterial evaluation of some new azaheterocycles with the 4,7-phenanthroline skeleton. Part VI

作者：Al Matarneh Cristina M; Ciobanu Catalina I; Mangalagiu Ionel I; Danac Ramona^*

来源：Journal of the Serbian Chemical Society, 2016, 81(2): 133-140.

DOI：10.2298/JSC150514084A

• p-halogenobenzoyl
• cycloimmonium salts
• antimycobacterial
• 4,7-phenanthroline
• N-alkylation

A feasibility study concerning the synthesis, structure and in vitro antimycobacterial evaluation of new 4,7-phenanthroline derivatives is reported. The preparation is straightforward and efficient, involving an N-alkylation reaction of 4,7-phenanthroline. The structure of the new compounds were verified by elemental and spectral (IR, H-1-and C-13-NMR) analysis. The in vitro antimycobacterial evaluation of the five synthesized compounds was investigated against Mycobacterium tuberculosis H37Rv under aerobic conditions. A certain influence of substituents on the para position of the benzoyl moiety was observed; the 4,7-phenanthrolin-4-ium salt substituted with p-chlorobenzoyl group showing the most pronounced antimycobacterial activity.

• 出版日期2016