Age of onset of hypertension and risk of dementia in the oldest-old: The 90+Study

作者：Corrada Maria M^*; Hayden Kathleen M; Paganini Hill Annlia; Bullain Szofia S; DeMoss Jaime; Aguirre Colette; Brookmeyer Ron; Kawas Claudia H

来源：Alzheimer's and Dementia, 2017, 13(2): 103-110.

DOI：10.1016/j.jalz.2016.09.007

• Hypertension
• Blood pressure
• Dementia
• Oldest-old
• Epidemiology
• Risk factors

Introduction: We investigated the association between age of onset of hypertension and dementia risk in an oldest-old cohort.
Methods: Participants are from The 90+ Study, a population-based longitudinal study of people aged 90+ who are survivors from the Leisure World Cohort Study. We estimated hypertension onset age using self-reported information from The 90+ Study and Leisure World Cohort Study, collected about 20 years earlier. A total of 559 participants without dementia were followed every 6 months for up to 10 years.
Results: A total of 224 participants developed dementia during follow-up (mean = 2.8 years). Compared with those without hypertension, participants whose hypertension onset age was 80 to 89 years had a lower dementia risk (hazard ratio = 0.58, P = .04) and participants with an onset age of 90+ years had the lowest risk (hazard ratio = 0.37, P = .004).
Discussion: Developing hypertension at older ages may protect against dementia. Understanding the mechanisms for this lower risk is important for determining ways to prevent dementia in the very elderly.

• 出版日期2017-2