科研之友
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摘要
The series of l,2,4-triazole derivatives containing methacrylic acid moiety were synthesized in reaction of N-3-substituted amidrazones with itaeonic anhydride. Preliminary calculated bioavailability parameters of obtained compounds suggested good penetration era cell membranes and their good absorption after oral intake. Antimicrobial evaluation in tint, showed diverse activity of obtained triazoles mainly on Grant-positive bacterial strains. One derivative was also examined to determine the effect on the central nervous system of mice.
- 出版日期2017-2
