Homogeneous Hydrogenation of Nitriles Catalyzed by Molybdenum and Tungsten Amides

作者：Chakraborty Subrata; Berke Heinz^*

来源：ACS Catalysis, 2014, 4(7): 2191-2194.

DOI：10.1021/cs5004646

• nitrile hydrogenation
• secondary imines
• molybdenum
• tungsten
• amides

Low-valent molybdenum and tungsten amides M(NO)(CO)-(PNP) {M = Mo, 1a; W, 1b; PNP = N((CH2CH2PPr2)-Pr-i)(2)} were found to be active catalysts for the hydrogenation of various nitriles to the corresponding imines, primary amines, and N-substituted imines with high selectivity for the latter type of product. A wide range of p- and m-substituted aromatic nitriles p-methyl, p-methoxy, p-bromobenzonitriles; 3-trifluoromethylbenzonitrile, m- and p-disubstituted benzonitrile; the heterocyclic 2-thiophencarbonitrile; and the aliphatic nitriles cyclohexylcarbonitrile and benzylcyanide-could be hydrogenated at 140 degrees C and 60 bar H-2 in THF with high yields. TOFs were found to be between 0.4 and 36 h(-1).

• 出版日期2014-7