Mixed-ligand nickel(II) thiosemicarbazone complexes: Synthesis, characterization and biological evaluation

作者：Saswati; Dinda Rupam^*; Schmiesing Carla S; Sinn Ekkehard; Patil Yogesh P; Nethaji M; Stoeckli Evans Helen; Acharyya Rama

来源：Polyhedron, 2013, 50(1): 354-363.

DOI：10.1016/j.poly.2012.11.031

• Thiosemicarbazone
• Nickel(II) complexes
• X-ray crystal structure
• Antibacterial study

The syntheses and characterization of some new mixed-ligand nickel(II) complexes {[Ni(L-1)(PPh3)] (1), [Ni(L-1)(Py)] (2), [Ni(L-2)(PPh3)]center dot DMSO (3), [Ni(L-2)(Imz)] (4), [Ni(L-3)(4-pic)] (5) and RNi(L-3))(2)(mu-4,4%26apos;-byp)]center dot 2DMSO (6)1 of three selected thiosemicarbazones [the 4-(p-X-phenyl)thiosemicarbazones of salicylaldehyde) (H2L1-3) (A, Scheme 1) are described in the present study, differing in the inductive effect of the substituent X (X = F, Br and OCH3), in order to observe its influence, if any, on the redox potentials and biological activity of the complexes. All the synthesized ligands and the metal complexes were successfully characterized by elemental analysis, IR, UV-Vis, NMR spectroscopy and cyclic voltammetry. The molecular structures of four mononuclear (1-3 and 5) and one dinuclear (6) Ni(II) complex have been determined by X-ray crystallography. The complexes have been screened for their antibacterial activity against Escherichia coli and Bacillus. The minimum inhibitory concentrations of these complexes and their antibacterial activities indicate that compound 4 is the potential lead molecule for drug designing.

• 出版日期2013-2-13