Association of two variants in the interleukin-6 receptor gene and premature coronary heart disease in a Chinese Han population

作者：Chen Zhong^*; Qian Qi; Tang Chengchun; Ding Jiandong; Feng Yi; Ma Genshan

来源：Molecular Biology Reports, 2013, 40(2): 1021-1026.

DOI：10.1007/s11033-012-2143-5

• Coronary heart disease
• Single nucleotide polymorphisms
• Gene
• Interleukin-6 receptor

Two novel single nucleotide polymorphisms (SNPs; rs7529229 and rs2228145) in the interleukin-6 receptor (IL6R) gene have recently been associated with coronary heart disease (CHD) in a European population. We sought to replicate this finding and to investigate associations of these two SNPs with the severity and clinical phenotypes of premature CHD in a Chinese Han population. A total of 418 patients were studied, including 187 cases with coronary stenosis a parts per thousand yen50 % or acute myocardial infarction (males < 55 years and females < 65 years) and 231 controls without documented CHD. A ligase detection reaction was performed to detect rs7529229 and rs2228145. There were no differences between the controls and premature CHD groups in the frequencies for the three genotypes and alleles of rs7529229 and rs2228145 (all P > 0.05), nor did they differ between the two groups when grouped by gender (all P > 0.05). There were also no associations between these two SNPs and the severity of coronary lesions or clinical phenotypes of premature CHD (all P > 0.05). Our results do not support an association between rs7529229 or rs2228145 with premature CHD in the Chinese Han population. Further studies are warranted to elucidate the role of these two SNPs in the development of atherosclerosis and CHD.

• 出版日期2013-2
• 单位南京医科大学; 东南大学