Downregulation of MTSS1 expression is an independent prognosticator in squamous cell carcinoma of the lung

作者：Kayser G^*; Csanadi A; Kakanou S; Prasse A; Kassem A; Stickeler E; Passlick B; zur Hausen A

来源：British Journal of Cancer, 2015, 112(5): 866-873.

DOI：10.1038/bjc.2015.2

• immunohistochemistry
• metastasis
• metastasis suppressor 1 (MTSS1)
• non-small-cell lung cancer
• survival

Background: The metastasis suppressor 1 (MTSS1) is a newly discovered protein putatively involved in tumour progression and metastasis.
Material and Methods: Immunohistochemical expression of MTSS1 was analysed in 264 non-small-cell lung carcinomas (NSCLCs).
Results: The metastasis suppressor 1 was significantly overexpressed in NSCLC compared with normal lung (P = 0.01). Within NSCLC, MTSS1 expression was inversely correlated with pT-stage (P = 0.019) and histological grading (P<0.001). NSCLC with MTSS1 downregulation (<20%) showed a significantly worse outcome (P = 0.007). This proved to be an independent prognostic factor in squamous cell carcinomas (SCCs; P = 0.041), especially in early cancer stages (P = 0.006).
Conclusion: The metastasis suppressor 1 downregulation could thus serve as a stratifying marker for adjuvant therapy in early-stage SCC of the lung.

• 出版日期2015-3-3