Daptomycin versus Vancomycin in Treatment of Methicillin-Resistant Staphylococcus aureus Meningitis in an Experimental Rabbit Model

作者：Bardak Ozcem Selin; Turhan Tuncer; Sipahi Oguz Resat^*; Arda Bilgin; Pullukcu Husnu; Yamazhan Tansu; Isikgoz Ta**akan Meltem; Sipahi Hilal; Ulusoy Sercan

来源：Antimicrobial Agents and Chemotherapy, 2013, 57(3): 1556-1558.

DOI：10.1128/AAC.01996-12

In this study, we aimed to compare the antibacterial activities of daptomycin and vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis (induced by MRSA strain ATCC 43300) in an experimental rabbit meningitis model. After an 8-h period of treatment, bacterial counts decreased significantly in both treatment groups compared to the control group (P<0.05). However, there was no statistically significant difference between treatment groups. Our results suggest that the antibacterial activity of daptomycin is similar to vancomycin for treatment in the experimental MRSA meningitis model in rabbits.

• 出版日期2013-3