Dietary Benzo[a]pyrene Intake from Meat and the Risk of Colorectal Cancer

作者：Tabatabaei Seyed Mehdi; Heyworth Jane S; Knuiman Matthew W; Fritschi Lin^*

来源：Cancer Epidemiology Biomarkers & Prevention, 2010, 19(12): 3182-3184.

DOI：10.1158/1055-9965.EPI-10-1051

Introduction: One possible mechanism for the postulated link between high consumption of meat and colorectal cancer (CRC) is the content of benzo[a]pyrene (BaP) in meat.
Methods: We investigated this association in a population-based case-control study in Western Australia (567 cases and 713 controls). Participants' self-report of meat consumption and lifestyle was used in conjunction with the CHARRED carcinogen database to estimate their BaP intake.
Results: Dietary exposure to BaP from meat consumption was not associated with the risk of CRC.
Conclusions: Our findings do not support the hypothesis that BaP exposure from meat consumption is a risk factor for CRC.
Impact statement: This large-scale case-control study used a detailed meat questionnaire in conjunction with the CHARRED database in a large population with high meat intake but was unable to find any association between intake of BaP and colorectal cancer. Cancer Epidemiol Biomarkers Prev; 19(12); 3182-4.

• 出版日期2010-12
• 单位河北医科大学