A Simple Copper-Catalyzed Synthesis of Tertiary Acyclic Amides

作者:Racine Emilie; Monnier Florian*; Vors Jean Pierre; Taillefer Marc
来源:Organic Letters, 2011, 13(11): 2818-2821.
DOI:10.1021/ol200750p

摘要

The N-arylation of aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, has been accomplished using a simple and cheap copper catalytic system. The corresponding tertiary acyclic amides, which can be found in numerous biologically active compounds, have been obtained in good to excellent yields.

  • 出版日期2011-6-3