Disrupting the stem cell niche: Good seeds in bad soil

作者:Perry John M; Li Linheng*
来源:Cell, 2007, 129(6): 1045-1047.
DOI:10.1016/j.cell.2007.05.053

摘要

Stem cells reside in a microenvironment or niche that is critical for stem cell maintenance and regulation. But what happens when a stem cell niche is disrupted? In this issue of Cell, two reports (Walkley et al., 2007a, 2007b) demonstrate in mice that alterations in the niche for hematopoietic stem cells lead to the development of myeloproliferative disease.