Non-invasive diagnostic approach to non-alcoholic fatty liver disease: current evidence and future perspectives

作者：Festi Davide^*; Schiumerini Ramona; Marasco Giovanni; Scaioli Eleonora; Pasqui Francesca; Colecchia Antonio

来源：Expert Review of Gastroenterology and Hepatology, 2015, 9(8): 1039-1053.

DOI：10.1586/17474124.2015.1049155

• liver fibrosis
• NAFLD
• NASH
• Non-invasive diagnosis
• steatosis
• transient elastography

Non-alcoholic fatty liver disease is a new epidemic liver disease, thus, its early diagnosis and the identification of those patients with the worst prognosis is mandatory. Liver biopsy is still the diagnostic gold standard, even if it is associated to a significant rate of complications; moreover, the interpretation of histological samples is not always univocal. Several non-invasive alternative scores have been proposed for the diagnostic approach to non-alcoholic fatty liver disease. This article evaluates the performance of the currently available non-invasive diagnostic strategies. The authors also suggest a potential diagnostic algorithm, with two or more non-invasive techniques, to increase the overall accuracy for identifying patients with worst prognosis, and to minimize the recourse to liver biopsy.

• 出版日期2015-8