Autonomic Dysfunction in Normal Tension Glaucoma: The Short-term Heart Rate Variability Analysis

作者：Na Kyung Sun; Lee Na Young; Park Sung Hwan; Park Chan Kee^*

来源：Journal of Glaucoma, 2010, 19(6): 377-381.

DOI：10.1097/IJG.0b013e3181c4ae58

• autonomic control
• heart rate variability
• normal tension glaucoma

Introduction: The purpose of this study was to investigate the dysfunction of autonomic control that may be a contributing factor in normal tension glaucoma (NTG) by showing the short-term heart rate variability in NTG patients.
Materials and Methods: Newly diagnosed NTG patients and an age-matched normal control group were enrolled in this prospective study. Blood pressure was obtained and the electrocardiogram was monitored for 5 minutes after 30-minute rest in a supine position. Electrocardiographic signals were transferred to a heart rate analyzer. The time and frequency domain parameters of heart rate variability were analyzed between two groups.
Result: In all, 77 NTG patients and 30 healthy controls were included in the study. There were no significant differences between NTG and controls with respect to age, sex, and a hypertensive history, heart rate, systolic pressure, and diastolic pressure. NTG patients showed a significant reduction in the standard deviation of the mean of qualified normal-to-normal intervals in comparison with controls (27.64 +/- 10.90 vs. 36.22 +/- 10.21, P = 0.041). Low-frequency values in NTG patients were statistically lower than in healthy controls (P = 0.001) and the low-frequency/high-frequency ratio was significantly higher in the NTG group (P = 0.000).
Discussion: Our study results showed that the dysfunction of an autonomic control is associated with NTG patients.

• 出版日期2010-8