A 256 Pixel Magnetoresistive Biosensor Microarray in 0.18 mu m CMOS

作者：Hall Drew A^*; Gaster Richard S; Makinwa Kofi A A; Wang Shan X; Murmann Boris

来源：IEEE Journal of Solid-State Circuits, 2013, 48(5): 1290-1301.

DOI：10.1109/JSSC.2013.2245058

• Biochip
• biosensor
• GMR spin-valve
• magnetic biosensor
• proteomics
• sigma delta modulator

Magnetic nanotechnologies have shown significant potential in several areas of nanomedicine such as imaging, therapeutics, and early disease detection. Giant magnetoresistive spin-valve (GMR SV) sensors coupled with magnetic nanotags (MNTs) possess great promise as ultra-sensitive biosensors for diagnostics. We report an integrated sensor interface for an array of 256 GMR SV biosensors designed in 0.18 mu m CMOS. Arranged like an imager, each of the 16 column level readout channels contains an analog front-end and a compact Sigma Delta modulator (0.054 mm(2)) with 84 dB of dynamic range and an input referred noise of 49 nT/root Hz. Performance is demonstrated through detection of an ovarian cancer biomarker, secretory leukocyte peptidase inhibitor (SLPI), spiked at concentrations as low as 10 fM. This system is designed as a replacement for optical protein microarrays while also providing real-time kinetics monitoring.

• 出版日期2013-5