Antibacterial Activity of Ecklonia cava Against Methicillin-Resistant Staphylococcus aureus and Salmonella spp.

作者：Choi Jang Gi; Kang Ok Hwa; Brice Obiang Obounou; Lee Young Seob; Chae Hee Sung; Oh You Chang; Sohn Dong Hwan; Park Hyun; Choi Han Gil; Kim Se Gun; Shin Dong Won; Kwon Dong Yeul^*

来源：Foodborne Pathogens and Disease, 2010, 7(4): 435-441.

DOI：10.1089/fpd.2009.0434

Ecklonia cava is a brown alga (Laminariales, Phaeophyta) growing on the subtidal rocky shores of Korea. It has antioxidant, antidiarrhea, and anticoagulant effects. In this study, the antimicrobial activity of E. cava EtOH extract and its fractions (n-hexane, CH(2)Cl(2), EtOAc, n-BuOH, and H(2)O) were investigated against methicillin-resistant Staphylococcus aureus and Salmonella spp. The E. cava EtOAc fraction showed good antibacterial activity against all bacteria. Eckol isolated from E. cava EtOAc fraction showed antimicrobial activity against all the tested strains. The minimum inhibitory concentration of eckol against S. aureus strains ranged from 125 to 250 mu g/mL and 125 to 250 mu g/mL for Salmonella strains. The fraction inhibitory concentration index of eckol in combination with ampicillin ranged from 0.31 to 0.5, indicating remarkable synergism against S. aureus. However, against Salmonella gallinarum ATCC 9184 and Salmonella typhimurium, it ranges from 0.75 to 1.0. The combinations of eckol + ampicillin exhibited improved inhibition of S. aureus and Salmonella with synergy or additive effect. We suggest that eckol ingredients of the E. cava against S. aureus and Salmonella have antibacterial activity.

• 出版日期2010-4