Toll-Like Receptors in Atherosclerosis

作者：Falck Hansen Mika; Kassiteridi Christina; Monaco Claudia^*

来源：International Journal of Molecular Sciences, 2013, 14(7): 14008-14023.

DOI：10.3390/ijms140714008

• pattern recognition
• inflammation
• toll-like receptors
• innate immunity
• atherosclerosis
• cardiovascular disease
• macrophages
• dendritic cells

Atherosclerosis, the leading cause of cardiovascular disease (CVD), is driven by inflammation. Increasing evidence suggests that toll-like receptors (TLRs) are key orchestrators of the atherosclerotic disease process. Interestingly, a distinct picture is being revealed for individual receptors in atherosclerosis. TLRs exhibit a complex nature enabling the detection of multiple motifs named danger-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs). Activation of these receptors triggers an intracellular signalling cascade mediated through MyD88 or TRIF, leading to the production of pro-and anti-inflammatory cytokines. In this review we explore key novel findings pertaining to TLR signalling in atherosclerosis, including recently described endosomal TLRs and future directions in TLR research.

• 出版日期2013-7