Fe3O4/TiO2 core/shell magnetic nanoparticle-based photokilling of pathogenic bacteria

作者：Chen Wei Jen; Chen Yu Chie^*

来源：Nanomedicine, 2010, 5(10): 1585-1593.

DOI：10.2217/NNM.10.92

• antibiotic-resistant
• magnetic nanoparticles
• pathogenic bacteria
• photokilling
• titania

Aims: We demonstrate a photokilling approach for pathogenic bacteria using magnetic nanoparticles as photokilling nanoprobes. Materials & methods: The nanoprobes are composed of iron oxide/titania (Fe3O4/TiO2) core/shell magnetic nanoparticles. The titanium layer on the magnetic nanoprobes plays two roles: as a photokilling agent and as an affinity substrate for pathogenic bacteria. The magnetic property of the nanoprobes allows the resultant nanoprobe-target species conjugates to be readily aggregated at a small spot under external magnetic field for conducting photokilling treatment. Therefore, damage to nontarget cells can be reduced. Results: The results show that Fe3O4/TiO2 core/shell magnetic nanoparticles do not only have the capacity to target pathogenic bacteria, including Gram-negative, Gram-positive and antibiotic-resistant bacteria, but they can also be used to effectively inhibit the cell growth of the bacteria (>99.9%) targeted by the magnetic nanoparticles under irradiation of a low-power UV lamp (lambda(max) similar to 306 nm, 0.412 mW/cm(2)) within 15 min. Conclusion: The potential application of this approach is in the treatment of cutaneous bacterial infections.

• 出版日期2010-12