Multi-scale analysis of neural activity in humans: Implications for micro-scale electrocorticography

作者：Kellis Spencer; Sorensen Larry; Darvas Felix; Sayres Conor; O'Neill Kevin III; Brown Richard B; House Paul; Ojemann Jeff; Greger Bradley^*

来源：Clinical Neurophysiology, 2016, 127(1): 591-601.

DOI：10.1016/j.clinph.2015.06.002

• Brain computer interface (BCI)
• Human cerebral cortex
• Micro-electrocorticography grid
• Neural engineering
• Neural microtechnology

Objective: Electrocorticography grids have been used to study and diagnose neural pathophysiology for over 50 years, and recently have been used for various neural prosthetic applications. Here we provide evidence that micro-scale electrodes are better suited for studying cortical pathology and function, and for implementing neural prostheses.
Methods: This work compares dynamics in space, time, and frequency of cortical field potentials recorded by three types of electrodes: electrocorticographic (ECoG) electrodes, non-penetrating micro-ECoG (mu ECoG) electrodes that use microelectrodes and have tighter interelectrode spacing; and penetrating microelectrodes (MEA) that penetrate the cortex to record single-or multiunit activity (SUA or MUA) and local field potentials (LFP).
Results: While the finest spatial scales are found in LFPs recorded intracortically, we found that LFP recorded from lECoG electrodes demonstrate scales of linear similarity (i.e., correlation, coherence, and phase) closer to the intracortical electrodes than the clinical ECoG electrodes.
Conclusions: We conclude that LFPs can be recorded intracortically and epicortically at finer scales than clinical ECoG electrodes are capable of capturing.
Significance: Recorded with appropriately scaled electrodes and grids, field potentials expose a more detailed representation of cortical network activity, enabling advanced analyses of cortical pathology and demanding applications such as brain-computer interfaces.

• 出版日期2016-1