Diversity, Structures, and Collagen-Degrading Mechanisms of Bacterial Collagenolytic Proteases

作者：Zhang Yu Zhong; Ran Li Yuan; Li Chun Yang; Chen Xiu Lan

来源：Applied and Environmental Microbiology, 2015, 81(18): 6098-6107.

DOI：10.1128/AEM.00883-15

<jats:title>ABSTRACT</jats:title><jats:p>Bacterial collagenolytic proteases are important because of their essential role in global collagen degradation and because of their virulence in some human bacterial infections. Bacterial collagenolytic proteases include some metalloproteases of the M9 family from<jats:named-content content-type="genus-species">Clostridium</jats:named-content>or<jats:named-content content-type="genus-species">Vibrio</jats:named-content>strains, some serine proteases distributed in the S1, S8, and S53 families, and members of the U32 family. In recent years, there has been remarkable progress in discovering new bacterial collagenolytic proteases and in investigating the collagen-degrading mechanisms of bacterial collagenolytic proteases. This review provides comprehensive insight into bacterial collagenolytic proteases, especially focusing on the structures and collagen-degrading mechanisms of representative bacterial collagenolytic proteases in each family. The roles of bacterial collagenolytic proteases in human diseases and global nitrogen cycling, together with the biotechnological and medical applications for these proteases, are also briefly discussed.</jats:p>

• 出版日期2015-9
• 单位微生物技术国家重点实验室