Abdominal transplantation for unresectable tumors in children: the zooming out principle

作者：Samuk Inbal^*; Tekin Akin; Tryphonopoulos Panagiotis; Pinto Ignacio G; Garcia Jennifer; Weppler Debbie; Levi David M; Nishida Seigo; Selvaggi Gennaro; Ruiz Phillip; Tzakis Andreas G; Vianna Rodrigo

来源：Pediatric Surgery International, 2016, 32(4): 337-346.

DOI：10.1007/s00383-015-3852-3

• Liver transplantation
• Multivisceral transplantation
• Intestinal autotransplantation
• Liver
• Neoplasms
• Unresectable abdominal neoplasms

To present our experience in abdominal transplantations to manage unresectable abdominal neoplasms in children and to describe the role of extensive surgeries in such cases.
This is a retrospective study of 22 abdominal transplantations in 21 patients for abdominal tumors over 16 years. Transplantation techniques included liver transplant (LT), multivisceral transplant (MVTx), and intestinal autotransplant (IA). Follow-up intervals ranged from 0.3 to 168 months (median 20 months).
LT alone was performed in 15 patients for primary malignant (11) and benign (4) liver tumors. Pathological classification included HB hepatoblastoma (6), HCC hepatocellular cancer (3), hepatic epithelioid hemangioendothelioma HEH (1), angiosarcoma (1), benign vascular tumors (3), and adenoma (1). IA was performed in four patients for lesions involving the root of the mesentery; tumors of the head of pancreas (3) and mesenteric hemangioma (1). MVTx was performed in 2 patients for malignancies; pancreaticoblastoma (1), recurrent hepatoblastoma (1), and in one patient as a rescue procedure after IA failure. Four of the eleven patients who underwent LT for malignant liver tumor had metastatic disease at presentation. Six of them died of recurrent neoplasm (3), transplant-related complications (2), and underlying disease (1). All LT patients who had benign tumors are alive with functioning grafts. All IA patients survived and are on an oral diet, with one patient requiring TPN supplementation. One of the three patients who underwent MVTx died of metastatic disease.
Allo/auto transplantation for abdominal tumors is a valuable modality when conventional treatments fail or are not feasible.

• 出版日期2016-4