Alkaloids from Corydalis saxicola and their anti-hepatitis B virus activity

作者：Li, Hui-Liang^*; Han, Ting; Liu, Run-Hui; Zhang, Chuan; Chen, Hai-Sheng; Zhang, Wei-Dong

来源：Chemistry and Biodiversity, 2008, 5(5): 777-783.

DOI：10.1002/cbdv.200890074

• HEPATOCELLULAR-CARCINOMA

Eight protoberberine-type alkaloids and two indole alkaloids were isolated from the MeOH extracts of the herb Corydalis saxicola BUNTING (Papaveraceae). Their structures were identified as clehydrocavidine (1), dehydroapocavidine (2), dehydroisoapocavidine (3), berberine (4), dehydroiso-corypalmine (5), coptisine (6), tetradehydroscoulerine (7), berbinium (8), 1-formyl-5-methoxy-6-methylindoline (9), and 1-formyl-2-hydroxy-5-methoxy-6-methylindoline (10). Compounds 3, 9, and 10 are new alkaloids. All compounds were tested for anti-HBV activity against the 2.2.15 cell line in vitro. Dehydrocavidine (1), dehydroapocavidine (2), and dehydroisoapocavidine (3) exhibited inhibitory activity against HBsAg and HBeAg, but no cytotoxicity against the 2.2.15 cell line.

• 出版日期2008
• 单位上海交通大学; 中国人民解放军第二军医大学