Neuroprotective Effect of Lipoxin A4 Methyl Ester in a Rat Model of Permanent Focal Cerebral Ischemia

作者：Wu, Yan; Ye, Xi-Hong; Guo, Pei-Pei; Xu, San-Peng; Wang, Jie; Yuan, Shi-Ying; Yao, Shang-Long; Shang, You^*

来源：Journal of Molecular Neuroscience, 2010, 42(2): 226-234.

DOI：10.1007/s12031-010-9355-8

• Focal permanent cerebral ischemia
• Lipoxin A(4) methyl ester

Neuroprotective effect of lipoxin A4 methyl ester (LXA(4) ME) was tested in a rat model of permanent middle cerebral artery occlusion. LXA(4) ME was administrated through intracerebroventricular injection immediately after middle cerebral artery was occluded. Administration of LXA(4) ME ameliorated neurological deficit, reduced infarct volume, attenuated histological damage, and decreased number of apoptotic neuron induced by ischemic insult. These neuroprotective effects of LXA(4) ME were associated with inhibition of neutrophil infiltration, lipid peroxidation, and astrocyte activation. In addition, LXA(4) ME also attenuated proinflammatory cytokines (TNF-alpha and IL-1 beta) production. These data suggest that LXA4 ME protects neuron against permanent cerebral ischemia by inhibiting inflammatory responses.

• 出版日期2010-10
• 单位华中科技大学