Aminophosphonic Acids - Phosphorus Analogues of Natural Amino Acids. Part 1: Syntheses of alpha-Aminophosphonic Acids

作者：Kudzin Zbigniew H^*; Kudzin Marcin H; Drabowicz Jozef; Stevens Chris V

来源：Current Organic Chemistry, 2011, 15(12): 2015-2071.

• alpha-aminophosphonic acids
• alpha-aminophosphonates
• phosphorus analogues of natural amino acids
• methods of synthesis of alpha-aminophosphonic acids
• Arbusov reaction
• Kabachnik-Medved reaction
• Fields reaction
• Michaelis-Becker reaction
• Moedritzer-Irani reaction
• Birum reaction
• Birum-Oleksyszyn reaction
• Oleksyszyn reaction
• PTC-aminoalkylphosphonate method
• hydrophosphonylation of multiple C-N bonds compounds
• 1-amination of functionalized phosphonates
• C-alkylation of phosphonoglycine derivatives
• Wittig-Horner reaction
• abbreviation code system for alpha-aminophosphonates

This review presents a comprehensive account of methods which are commonly applied for the synthesis of alpha- aminophosphonic acids. In the following order, protocols based on the methodologies listed below are discussed: a) simultaneous formation of P-C-N systems; b) nucleophilic substitution with phosphoroorganic nucleophiles; c) additions of the P-H functions to multiple C-N bonds; d) alpha-amination of phosphonates and functionalized alkylphosphonates; e) modifications of the side chain of aminoalkylphosphonates; f) modifications of phosphorus functions and h) modifications of functions containing nitrogen.

• 出版日期2011-6