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摘要
A direct fluorination of 4,6-disubstituted 2-amino-pyrimidines with Selectfluor in the presence of Ag(I) is presented, affording the corresponding 4,6-disubstituted 5-fluoro-2-aminopyrimidines with acceptable to high yield. Ag(I) is crucial for this chemoselective fluorination process. The transformation of 4,6-diphenyl 5-fluoro-2-aminopyrimidine into N-(5-fluoro-4,6-diphenylpyrimidin-2-y1)-4-methylbenzenesulfonamide is discussed, and the reaction mechanism is investigated, as well.
- 出版日期2017-1-20
- 单位同济大学
