Microwave-assisted TsOH/SiO2-catalyzed one-pot synthesis of novel fluoro-substituted coumarin hydrazones under solvent-free conditions

作者：Yang, Guo-Yu; Yang, Jing-Tian; Wang, Cai-Xia; Fan, Su-Fang; Xie, Pu-Hui; Xu, Cui-Lian^*

来源：Journal of Fluorine Chemistry, 2014, 168: 1-8.

DOI：10.1016/j.jfluchem.2014.07.004

• Microwave-assisted
• One-pot synthesis
• Coumarin hydrazones
• Fluorine

Sixteen novel fiuoro-substituted coumarin hydrazones were synthesized from a series of ethyl 2-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylates with supported acid catalyst under microwave-assisted one-pot and solvent free conditions. The structures of synthesized compounds were confirmed by IR, H-1 NMR, C-13 NMR, HRMS and single crystal X-ray diffraction. Compared with the reported reaction conditions, the new method has the advantages of shorter reaction time, simple workup procedure and environmental friendliness. The supported catalyst can be recovered easily and reused with little change in its activity.

• 出版日期2014-12
• 单位河南农业大学