A Green and Efficient One-Pot Pseudo-Five-Component Reaction for Synthesis of Bis(pyrazol-5-ol) Derivatives via Tandem Cyclocondensation-Knoevenagel-Michael Reaction

作者：Yang, Cheng; Liu, Peng-Ze; Xu, Da-Zhen^*

来源：ChemistrySelect, 2017, 2(3): 1232-1236.

DOI：10.1002/slct.201601801

• aqueous media
• bis(pyrazol-5-ol)s
• ionic liquid
• multi-component tandem reactions
• recyclability

A simple, green and efficient approach for one-pot pseudo-five-component synthesis of the 4,4'-(arylmethylene) bis(1H-pyrazol-5-ol) derivatives from hydrazines, dialkyl acetylenedicarboxylats/beta-ketoesters and aromatic aldehydes catalyzed by Dabco-base ionic liquids in aqueous media has been successfully developed. All the reactions were performed under 3 mol% of ionic liquid catalyst, and afforded the corresponding bis(pyrazol-5-ol)s in excellent yields (81-98 %). This method also offers several other notable advantages, such as environmental friendliness, short reaction times, easy workup and reusability of the inexpensive catalyst.

• 出版日期2017-1
• 单位南开大学