Adipocytokines in Relation to Hodgkin Lymphoma in Children

作者：Petridou Eleni Th^*; Dessypris Nick; Panagopoulou Paraskevi; Sergentanis Theodoros N; Mentis Alexios Fotios A; Pourtsidis Apostolos; Polychronopoulou Sophia; Kalmanti Maria; Athanasiadou Piperopoulou Fani; Moschovi Maria

来源：Pediatric Blood and Cancer, 2010, 54(2): 311-315.

DOI：10.1002/pbc.22294

• adiponectin
• child
• Hodgkin lymphoma
• immunology
• leptin

This case-control Study aims to explore the association of serum adiponectin/leptin with childhood Hodgkin lymphoma (HL). Study participants were 75 children with histologically confirmed HL, registered in the Nationwide Registry for Childhood Haematological Malignancies and 75 age- and gender-matched controls. Multiple conditional logistic regression analyses were performed, adjusting for sociodemographic and lifestyle parameters. Adiponectin levels were consistently higher among cases in all models with ORs >1.25; 95% CIs ranging from 0.9 to 1.8 and P-values from 0.09 to 0.20. By contrast, there was no association of serum leptin with HL. In Conclusion, elevated Serum adiponectin might be a risk factor for childhood HL. Pediatr Blood Cancer 2010;54:311-315.

• 出版日期2010-2