An Efficient Synthesis of Multi-Substituted 3,4-Dihydropyrimidin-2(1H)-ones/thiones Under Solvent-Free Microwave Irradiation Using Alumina Sulfuric Acid

作者：Shaterian Hamid Reza^*; Hosseinian Asghar; Ghashang Majid

来源：Phosphorus, Sulfur, and Silicon and the Related Elements, 2009, 184(1): 197-205.

DOI：10.1080/10426500802083182

• Biginelli reaction
• dihydropyrimidinone/thione
• heterogeneous catalyst
• microwave
• multi-component reaction
• solvent-free

A new and efficient method for the synthesis of multi-substituted dihydropyrimidinone derivatives or their sulfur analogs has been developed under solvent-free microwave irradiation conditions in the presence of alumina sulfuric acid (Al2O3-SO3H) as an environmentally friendly heterogeneous recyclable catalyst, in high yields and short reaction time.

• 出版日期2009