科研之友
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摘要
Objective: conventional vascular risk factors (VRFs) are associated with cognitive impairment independent of stroke and detectable cerebral lesions. We used proton magnetic resonance spectroscopy (H-1 MRS) to examine the hypotheses that abnormal levels of brain metabolites may mediate the relationship between VRFs and cognitive impairment. Methods: a group of 54 stroke-free subjects with various VRFs underwent comprehensive cognitive assessments and H-1 MRS scan of the left hippocampus and prefrontal cortex. We indirectly measured the concentrations of N-acetylaspartate (NAA), choline, inositol, creatine (Cr) and total concentrations of glutamate plus glutamine (Glx). VRFs were quantified by Framingham stroke risk profile (FSRP) score. Subjects were divided into low- (<10%), medium- (10-20%) and high-risk (>20%) groups according to their FSRP scores. Pearson and partial correlation analysis were used to investigate the correlation between FSRP scores and cognitive performance along with the brain metabolism. Results: compared with subjects in low-risk group, high-risk group subjects had significantly poor performances on the tasks of working memory, delayed recall and executive function. In high-risk group, hippocampal Glx/Cr ratios and prefrontal NAA/Cr ratios were significantly lower than those in low-risk group. Lower prefrontal NAA/Cr ratios were associated with executive dysfunction, and lower hippocampal Glx/Cr ratios were associated with impaired delayed recall. Conclusion: abnormal concentrations of brain metabolites and decreased glutamate plus glutamine concentration may play an important role in the pathophysiology of VRF-associated cognitive impairment. Brain metabolites detected by 1H MRS may serve as important markers for monitoring VRFs burden.
- 出版日期2014-9
- 单位武汉大学
