Association between genotype and allele frequencies of CYP2A6(star)12 and rs16969968 in CHRNA5 variants with smoking and body mass index in young subjects from Northeast Mexico

作者：Borrego Soto Gissela; Costilla Esquivel Antonio; Raymundo Padilla Rivas Gerardo; Janeth Cazares Samaniego Paulina; Posadas Valay Rodolfo; Gerardo Velasco Castanon Jose; Mercado Longoria Roberto; Ortiz Lopez Rocio; Rojas Martinez Augusto^*

来源：Revista Medica de Chile, 2015, 143(11): 1377-1385.

• Body mass index
• Genetic variation
• Nicotine
• Smoking

Background: Several studies have reported that variants rs16969968 G>A of the CHRNA5 gene and CYP2A6(star)12 of the CYP2A6 gene are associated with smoking and smoking refusal, respectively. In addition, some studies report that a higher cigarette consumption is associated with low body mass index (BMI). Aim: To analyze the allele and genotypic frequencies of these variants and their impact on smoking and BMI Material and Methods: A blood sample was obtained and a survey about smoking habits was answered by 319 university students aged 18 to 35 years (127 women, 171 smokers), living in Northeastern Mexico. Genetic variants were studied by polymerase chain reaction/restriction fragment length polymorphism and their frequencies were associated with smoking and BMI. Results: No associations were found between the analyzed variants and smoking in the study groups. However, there was an association among non-smoking subjects between the A allele of rs16969968 and high a BMI (p < 0.01). Conclusions: This last variant may be involved in food-addiction disorders.

• 出版日期2015-11