A case of HIV-associated diffuse infiltrative lymphocytosis syndrome simulating primary Sjogren Syndrome and BALT Lymphoma

作者：Rovisco J^*; Santiago T; Ines L

来源：Acta Reumatologica Portuguesa, 2015, 40(1): 68-71.

• Sjogren's syndrome
• HIV
• DILS

Diffuse infiltrative lymphocytic syndrome (DILS) is a clinical identity that can be part of the spectrum of Human Immunodeficiency Virus (HIV) infection. It is characterized by sicca symptoms, parotid and lachrymal enlargement and extra-articular manifestations.
We report the case of a 60-years-old woman with clinical sicca syndrome in association with leukopenia, positive anti-nuclear antibody (ANA) and polyclonal hypergammaglobulinemia. During the follow-up the patient developed a mucosa-associated lymphoid tissue pulmonary neoplasm. Furthermore, the clinical diagnosis work-up revealed human immunodeficiency virus (HIV) positive serology.
In this particular case report, we must underline the clinical presentation of a sicca syndrome as a manifestation of the HIV infection, bearing in mind that, frequently, the differential diagnosis from other diseases, namely the Sjogren's syndrome, is a real challenge.

• 出版日期2015-3