Anticonvulsant Activity and Toxicity Evaluation of Cu-II and Zn-II Metal Complexes Derived from Triazole-Quinoline Ligands

作者:Kulkarni Naveen Vasudev; Budagumpi Srinivasa; Kurdekar Gurunath Suresh; Revankar Vidyanand Krishna*; Didagi Suresh
来源:CHEMICAL & PHARMACEUTICAL BULLETIN, 2010, 58(12): 1569-1575.
DOI:10.1248/cpb.58.1569

摘要

A novel Cu-II and Zn-II complexes of triazolo-quinoline derivatives were synthesized by in situ method and were characterized by the spectro-analytical methods and their pharmacological properties were evaluated. The compound C3 has exhibited promising anticonvulsant activity towards the electroshock Induced seizures in Wistar rats and possesses low toxicity, providing a high safety profile.

  • 出版日期2010-12