Atherosclerosis risk in HIV-infected patients: The influence of hepatitis C virus co-infection

作者：Sosner Philippe^*; Wangermez Marc; Chagneau Derrode Carine; Le Moal Gwenael; Silvain Christine

来源：Atherosclerosis, 2012, 222(1): 274-277.

DOI：10.1016/j.atherosclerosis.2012.02.027

• Atherosclerosis
• Hepatitis C
• HIV
• Intima-media thickness
• Liver fibrosis

Background: The influence of hepatitis C virus (HCV) infection on atherosclerosis risk in HIV-infected patients has not been adequately evaluated in real-life situations. %26lt;br%26gt;Objectives and methods: We compared indexes of early atherosclerosis evaluated by echo-Doppler ultrasound (presence of plaque in carotid or femoral arteries) in 18 HCV-HIV co-infected patients versus 22 HIV mono-infected patients. %26lt;br%26gt;Results: Prevalence of subclinical carotid plaque was significantly higher in HCV-HIV co-infected patients (p = 0.04), despite of the fact LDL-cholesterol and blood pressure (BP) were lower in the co-infected patients (p = 0.003). HCV chronic infection (OR = 10; IC: 1.5-72; p = 0.02) was an independent risk factor. %26lt;br%26gt;Conclusion: This cross sectional study suggests that HCV infection might be an independent cardiovascular risk factor in HCV-HIV co-infected patients. HCV infection might be considered as not only a liver infection but also as a metabolic disease in HIV patients, justifying regular cardiovascular surveillance.

• 出版日期2012-5